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Biomimetic Nanopillared Surfaces Inhibit Drug Resistant Filamentous Fungal Growth

Rachel Rosenzweig, Michaela Marshall, Alex Parivar

    ACS Applied Bio Materials
    |January 15, 2022
    PubMed

    Insights

    Biomimetic nanopillars effectively inhibit filamentous fungi growth and kill fungal spores. This innovation offers promising antifungal properties for biomedical devices and implants, preventing contamination and biofilm formation.

    Area of Science:

    • Biomaterials Science
    • Mycology
    • Surface Science

    Background:

    • Filamentous fungi are resilient pathogens causing infections on biomedical devices.
    • Fungal spores form biofilms, complicating treatment and device longevity.
    • Natural nanotopography exhibits antimicrobial effects on bacterial adhesion.

    Purpose of the Study:

    • To investigate the antifungal efficacy of biomimetic nanopillars against filamentous fungi.
    • To explore the potential of nanotopography in preventing fungal contamination on surfaces.
    • To assess the impact of nanopillars on fungal spore viability and growth.

    Main Methods:

    • Fabrication of biomimetic nanopillar surfaces.
    • Inoculation with filamentous fungal spores.
    • Microscopic analysis of fungal adhesion, germination, and biofilm formation.
    • Assessment of spore morphology and viability on nanopillar and flat surfaces.

    Main Results:

    • Nanopillars significantly inhibited filamentous fungal growth and biofilm formation.
    • Fungal spores on nanopillars showed reduced viability and altered morphology (deflated appearance).
    • Flat surfaces supported spherical, intact fungal spores and subsequent growth.

    Conclusions:

    • Biomimetic nanopillars demonstrate potent fungicidal and fungistatic properties.
    • Nanotopography offers a promising strategy for developing antifouling biointerfaces.
    • This approach has significant implications for preventing fungal contamination in biomedical applications.
    Keywords:
    Aspergillus fumigatusFusarium oxysporumantifoulingantifungalfilamentous funginanopillared surfaces

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