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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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Updated: Oct 6, 2025

Generation of Alginate Microspheres for Biomedical Applications
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Biodegradable Alginate Polyelectrolyte Capsules As Plausible Biocompatible Delivery Carriers.

Sathi Roy1, Nancy M Elbaz2, Wolfgang J Parak1

  • 1Faculty of Physics, Center for Hybrid Nanostructures (CHyN), Universität Hamburg, Hamburg, Germany.

ACS Applied Bio Materials
|January 15, 2022
PubMed
Summary
This summary is machine-generated.

Biodegradable polyelectrolyte capsules were developed for drug delivery. These alginate capsules effectively encapsulate curcumin, showing pH-dependent release and good biocompatibility for potential therapeutic applications.

Keywords:
biocompatiblebiodegradable polyelectrolyte capsulesdrug releaselayer-by layer assemblynanomaterials

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Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Polyelectrolyte capsules offer versatile systems for compound encapsulation and delivery.
  • Biodegradable polymers are crucial for developing safe and effective drug delivery vehicles.
  • Curcumin exhibits significant therapeutic potential due to its antioxidant, anti-inflammatory, and anticancer properties.

Purpose of the Study:

  • To synthesize biocompatible and biodegradable polyelectrolyte capsules using alginate and poly-l-arginine.
  • To incorporate a pH-sensitive outer layer using EUDRAGIT L 100 for controlled drug release.
  • To load curcumin into the capsules and evaluate their performance as a drug delivery system.

Main Methods:

  • Layer-by-layer (LbL) assembly was employed to construct capsules with dimensions under 1 μm.
  • Capsules were characterized for stability, loading efficiency, drug release kinetics, and degradation at varying pH.
  • In vitro biocompatibility and cellular uptake studies were conducted using HeLa cells.

Main Results:

  • The synthesized alginate/poly-l-arginine capsules demonstrated good reproducibility, spherical morphology, and high monodispersibility.
  • High loading efficiency for curcumin was achieved, with pH-dependent drug release profiles observed.
  • In vitro studies confirmed acceptable biocompatibility and significant cellular internalization of the capsules.

Conclusions:

  • Alginate-based layer-by-layer capsules with a pH-sensitive outer layer are effective for curcumin encapsulation and delivery.
  • These capsules exhibit favorable characteristics for drug delivery, including controlled release and good biocompatibility.
  • The study suggests the potential of these alginate capsules as efficient drug carriers for therapeutic applications.