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Updated: Oct 6, 2025

Bioluminescent Optogenetics 2.0: Harnessing Bioluminescence to Activate Photosensory Proteins In Vitro and In Vivo
Published on: August 4, 2021
Optogenetic approaches in biotechnology and biomaterials
Vasily V Reshetnikov1, Sviatlana V Smolskaya2, Sofia G Feoktistova2
1Science Center for Genetics and Life Sciences, Sirius University of Science and Technology, Sochi 354340, Russia; Department of Molecular Genetics, Institute of Cytology and Genetics, Novosibirsk 630009, Russia.
Abstract:
Advances in genetic engineering, combined with the development of optical technologies, have allowed optogenetics to broaden its area of possible applications in recent years. However, the application of optogenetic tools in industry, including biotechnology and the production of biomaterials, is still limited, because each practical task requires the engineering of a specific optogenetic system. In this review, we discuss recent advances in the use of optogenetic tools in the production of biofuels and valuable chemicals, the synthesis of biomedical and polymer materials, and plant agrobiology. We also offer a comprehensive analysis of the properties and industrial applicability of light-controlled and other smart biomaterials. These data allow us to outline the prospects for the future use of optogenetics in bioindustry.

