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Ocular hypertensive responses in pigmented rabbits following different methods of waterloading
A J Flach1, J S Peterson, M E Donahue
1Department of Ophthalmology, Veterans Administration Medical Center, San Francisco, California.
Journal of Ocular Pharmacology
|January 1, 1986
Abstract:
Waterloading tests are used in rabbits to screen potentially useful ocular hypotensive drugs. The present study examines the ocular hypertensive response following oral, intravenous and intraperitoneal administration of water in conscious Dutch belt pigmented rabbits. All methods of waterloading were well tolerated by rabbits. However, intraperitoneal waterloading provided an ocular hypertensive effect of longer duration than either oral or intravenous waterloading.