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Updated: Oct 6, 2025

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
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Spectrum of microRNAs and their target genes in cancer: intervention in diagnosis and therapy

Alti Dayakar1, Kumar D Shanmukha2, Suresh K Kalangi3

  • 1Independent Researcher, Vizianagaram, India.

Molecular Biology Reports
|January 15, 2022
PubMed

Insights

MicroRNAs (miRNAs) play dual roles in cancer, acting as tumor promoters or suppressors. Understanding miRNA dysregulation is key for developing novel cancer diagnostics and therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are crucial regulators of gene expression.
  • Aberrant miRNA biogenesis, processing, stability, and silencing are implicated in cancer development.
  • miRNA genes undergo genetic and epigenetic alterations in cancerous cells.

Purpose of the Study:

  • To review the role of miRNAs and their target genes across various cancers.
  • To explore the potential of miRNAs in cancer diagnosis and therapy.
  • To examine the influence of miRNAs on drug sensitivity and resistance in cancer treatment.

Main Methods:

  • Literature review of studies on miRNA mechanisms in cancer.
  • Analysis of miRNA involvement in tumor promotion and suppression.
  • Compilation of data on miRNA dysregulation in diverse cancer types.

Main Results:

  • miRNAs exhibit context-dependent functions as oncogenes or tumor suppressors.
  • Specific miRNAs are associated with altered gene expression in cancer.
  • miRNA profiles correlate with cancer progression and therapeutic outcomes.

Conclusions:

  • miRNAs represent promising biomarkers for cancer diagnosis and prognosis.
  • Targeting miRNAs offers a potential therapeutic strategy for cancer intervention.
  • Further research into miRNA-cancer interactions can guide personalized cancer treatment.
Keywords:
CancerDiagnosisEpigeneticsMicroRNATherapy

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