Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells and Secretions of the Pancreas01:16

Cells and Secretions of the Pancreas

3.1K
The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
3.1K
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.8K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.8K
Epithelial Tissues and Their Functions01:23

Epithelial Tissues and Their Functions

28.2K
Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
Epithelial tissues provide the body's first line of protection from physical,...
28.2K
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.3K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.3K
The Parathyroid Glands00:59

The Parathyroid Glands

2.7K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.7K
Microvilli00:55

Microvilli

7.7K
Microvilli are tiny finger-like projections found on the surface of certain cells. Their purpose is to increase the surface area of the cell's apical surface, resulting in more effective absorption or secretion of substances.
These microvilli are predominantly present in cells lining the small intestine, kidney tubules, and certain cells in the respiratory and reproductive systems. By significantly expanding the surface area of the cell membrane, microvilli enhance the cell's capacity...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distribution of Troy (Tnfrsf19) in the Gastric Gland During Postnatal Development: Effects of Early Weaning.

Cell biology international·2025
Same author

Breastfeeding lifespan control of growth, maintenance, and metabolism of small intestinal epithelium.

Journal of cellular physiology·2023
Same author

Breastfeeding importance and its therapeutic potential against SARS-CoV-2.

Physiological reports·2021
Same author

Neonatal- maternal separation primes zymogenic cells in the rat gastric mucosa through glucocorticoid receptor activity.

Scientific reports·2018

Related Experiment Video

Updated: Oct 6, 2025

Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models
07:48

Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models

Published on: November 21, 2015

17.8K

Paneth cells and their multiple functions.

Laylla Barreto E Barreto1, Isadora C Rattes1, Aline V da Costa1

  • 1Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, State of São Paulo, Brazil.

Cell Biology International
|January 15, 2022
PubMed
Summary

Paneth cells in the small intestine defend against microbes and regulate stem cells. Their dysfunction in diseases like Crohn's disease compromises gut health and regeneration.

Keywords:
cell cyclecell differentiationgrowth factorsstem cells

More Related Videos

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses
07:42

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Published on: July 13, 2016

70.4K
Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry
05:38

Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry

Published on: January 28, 2017

12.4K

Related Experiment Videos

Last Updated: Oct 6, 2025

Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models
07:48

Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models

Published on: November 21, 2015

17.8K
Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses
07:42

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Published on: July 13, 2016

70.4K
Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry
05:38

Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry

Published on: January 28, 2017

12.4K

Area of Science:

  • Gastroenterology
  • Cell Biology
  • Immunology

Background:

  • The small intestine mucosa features a crypt-villus axis lined by specialized epithelial cells.
  • Paneth cells, located at the crypt base, contain antimicrobial peptides and growth factors crucial for intestinal health.
  • These cells play vital roles in host defense, microbiota regulation, and stem cell niche maintenance.

Purpose of the Study:

  • To review the key characteristics and functions of Paneth cells.
  • To emphasize the importance of Paneth cells in maintaining intestinal homeostasis.
  • To discuss the consequences of Paneth cell dysfunction in various pathologies.

Main Methods:

  • This is a review article, synthesizing existing research on Paneth cells.
  • Literature search and analysis of studies focusing on Paneth cell biology and pathology.
  • Compilation of information on Paneth cell composition, functions, and roles in disease.

Main Results:

  • Paneth cells secrete antimicrobial peptides (e.g., defensins, lysozyme) and growth factors (e.g., EGF, TGF-α, Wnt ligands).
  • These secretions are essential for combating pathogens, managing gut microbiota, and preserving stem cell identity.
  • Pathologies such as Crohn's disease, necrotizing enterocolitis, and graft-versus-host disease reduce Paneth cell populations, impairing defense and regeneration.

Conclusions:

  • Paneth cells are critical for intestinal barrier function and tissue renewal.
  • Loss or dysfunction of Paneth cells leads to increased susceptibility to infections and dysbiosis.
  • Preserving Paneth cell integrity is essential for maintaining overall bowel homeostasis and health.