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Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
Published on: February 9, 2024
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Thyroid disorders and cardiovascular manifestations: an update
Stavroula A Paschou1, Evanthia Bletsa2, Panagiota K Stampouloglou2
1Endocrine Unit and Diabetes Centre, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. s.a.paschou@gmail.com.
Endocrine
|January 15, 2022
Summary
Thyroid disorders significantly impact cardiovascular health, increasing mortality risk. Early management of hyperthyroidism and hypothyroidism is crucial for cardiovascular disease prevention.
Area of Science:
- Endocrinology
- Cardiology
- Molecular Medicine
Background:
- Cardiovascular disease (CVD) is a leading global cause of death.
- Thyroid disorders affect over 10% of adults, presenting a significant public health challenge.
Purpose of the Study:
- To elucidate the physiological role of thyroid hormones in the cardiovascular system.
- To detail cardiovascular manifestations in thyroid disorders, focusing on molecular and biochemical pathways.
- To summarize current therapeutic strategies for thyroid-related cardiovascular complications.
Main Methods:
- Literature review synthesizing existing research on thyroid hormones and cardiovascular function.
- Analysis of molecular mechanisms linking thyroid dysfunction to cardiovascular pathologies.
- Review of clinical guidelines and treatment options for managing cardiovascular aspects of thyroid disorders.
Main Results:
- Thyroid hormone receptors in myocardium and vessels directly influence cardiovascular function.
- Both hyperthyroidism and hypothyroidism, even subclinical forms, can accelerate CVD progression.
- Thyroid disorders contribute to dyslipidemia, hypertension, myocardial dysfunction, and endothelial dysfunction.
Conclusions:
- Thyroid hormone levels critically affect cardiovascular health.
- Untreated thyroid disorders significantly elevate cardiovascular mortality.
- Targeted management of subclinical hypothyroidism in younger and subclinical hyperthyroidism in elderly populations is recommended.
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