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Updated: Oct 6, 2025
14:48
Proteomic Profile of EPS-Urine through FASP Digestion and Data-Independent Analysis
Published on: May 8, 2021
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Urinary Proteomics in Kidney Transplantation.
Goce Spasovski1, Irena Rambabova-Bushljetik1, Lada Trajceska1
1Department of Nephrology, Medical Faculty, University of Ss. Cyril and Methodius, Skopje, N. Macedonia.
Summary
Urinary proteomics may help identify kidney transplant recipients at risk for graft failure early. This approach offers potential for improved screening and personalized treatment strategies in transplantation medicine.
Area of Science:
- Nephrology
- Proteomics
- Transplantation Medicine
Background:
- Kidney transplantation is optimal for end-stage kidney disease but faces long-term graft failure.
- Early identification of high-risk grafts before irreversible damage is a significant challenge.
- Novel biomarkers are needed for preventive screening, early diagnosis, and improved prognosis.
Purpose of the Study:
- To review the clinical application of urinary proteomics.
- To assess its utility in kidney transplant recipients at risk for graft failure.
Main Methods:
- Literature review of studies on urinary proteomics in kidney transplant recipients.
- Analysis of biomarker identification and clinical utility.
Main Results:
- Urinary proteomics shows promise in identifying subtle changes indicative of future graft failure.
- Specific protein patterns may serve as early warning signs for adverse outcomes.
- Further validation is needed for widespread clinical adoption.
Conclusions:
- Urinary proteomics represents a promising, non-invasive tool for early graft failure risk assessment.
- This approach can aid in timely interventions and personalized management of kidney transplant recipients.
- Future research should focus on standardizing methods and validating findings in larger cohorts.
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