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Cerebral blood flow self-regulation in depression
Min Liu1, Enling He1, Xiyao Fu1
1Department of Neurology, The First Hospital of Jilin University, No.1, Xinmin Street, Changchun, China.
Journal of Affective Disorders
|January 15, 2022
Summary
Cerebral blood flow self-regulation (CBFSR) is impaired in depression, impacting neurological symptoms. This review explores the mechanisms linking depression and impaired CBFSR, offering insights into patient conditions.
Area of Science:
- Neuroscience
- Psychiatry
- Vascular Biology
Background:
- Depression is a prevalent neuropsychiatric disorder often presenting with neurological symptoms like sleep disturbances, memory decline, dizziness, and headaches.
- Abnormalities in cerebral blood flow (CBF) are observed in depressed patients, even without structural brain damage.
- Cerebral blood flow self-regulation (CBFSR) is crucial for maintaining stable CBF amidst neurological and metabolic changes.
Purpose of the Study:
- To review and discuss the state of cerebral blood flow self-regulation (CBFSR) in patients diagnosed with depression.
- To explore the relationship between the pathogenesis of depression and alterations in CBFSR.
- To elucidate the potential mechanisms underlying impaired CBFSR in the context of depression.
Main Methods:
- A literature search was conducted using keywords including "depression", "cerebral blood flow", "cerebral autoregulation", and "cerebrovascular reactivity".
- The review analyzed changes in CBFSR in depression and its potential link to the disease's development.
- Possible mechanisms of impaired CBFSR in depressed individuals were investigated.
Main Results:
- The literature review indicates a significant impairment of CBFSR in patients with depression.
- Abnormal levels of circulating markers, including those for endothelial dysfunction, nitric oxide, inflammatory cytokines, glucocorticoids, and monoamine neurotransmitters, were frequently observed.
- These biochemical alterations were found to affect CBFSR to varying degrees in depressed individuals.
Conclusions:
- Cerebral blood flow self-regulation (CBFSR) is demonstrably impaired in individuals experiencing depression.
- Underlying mechanisms contributing to impaired CBFSR in depression include endothelial dysfunction, microglial activation, cytokine dysregulation, HPA axis hyperactivation, oxidative stress, and monoamine neurotransmitter imbalances.
- Understanding these mechanisms enhances comprehension of the clinical manifestations observed in depressed patients.
Keywords:
Biological mechanismsCerebral autoregulationCerebral blood flow self-regulationCerebrovascular reactivityDepressionMore Related Videos
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