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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

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Signaling pathways modulated by miRNAs in breast cancer angiogenesis and new therapeutics

Bashdar Mahmud Hussen1, Abbas Salihi2, Sara Tharwat Abdullah3

  • 1Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq; Center of Research and Strategic Studies, Lebanese French University, Erbil, Kurdistan Region, Iraq.

Pathology, Research and Practice
|January 15, 2022
PubMed

Insights

MicroRNAs (miRNAs) regulate tumor angiogenesis, a key process in cancer growth and metastasis. This study explores miRNA-controlled pathways and delivery methods for anti-angiogenic cancer therapies.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Biochemistry

Background:

  • Tumor development and metastasis heavily rely on angiogenesis, the formation of new blood vessels.
  • MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and are implicated in various biological processes, including cancer.
  • Endothelial cell (EC) activity is crucial for angiogenesis and is modulated by miRNAs through diverse signaling pathways.

Purpose of the Study:

  • To elucidate miRNA-regulated signaling pathways involved in tumor angiogenesis.
  • To highlight the response to anti-angiogenic therapy.
  • To review miRNA delivery methods for inhibiting angiogenesis.

Main Methods:

  • Review of existing literature on miRNA function in angiogenesis.
  • Analysis of miRNA-regulated signaling pathways in cancer.
  • Examination of in vitro and in vivo studies on miRNA-based anti-angiogenic strategies.

Main Results:

  • MicroRNAs can act as oncogenes or tumor suppressors, influencing angiogenic signaling.
  • Tumor-derived extracellular vesicles can deliver miRNAs to ECs, impacting angiogenesis.
  • MiRNAs show significant potential as therapeutic agents to inhibit tumor angiogenesis.

Conclusions:

  • Understanding miRNA-regulated pathways is crucial for developing effective anti-angiogenic cancer therapies.
  • Targeted delivery of miRNAs offers a promising strategy for cancer treatment by inhibiting angiogenesis.
  • Further research into miRNA mechanisms and delivery systems can advance cancer therapy.
Keywords:
Breast cancerMiRNAMiRNA deliveryTherapyTumor angiogenesisVEGF

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