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Updated: Oct 6, 2025

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Heart failure with preserved ejection fraction: Squaring the circle between comorbidities and cardiovascular
Alberto Maria Marra1, Leonardo Bencivenga2, Roberta D'Assante3
1Department of Translational Medical Sciences, University of Naples "Federico II", Napoli, Italy; Interdisciplinary Research Centre on Biomaterials (CRIB), Federico II University, Naples, Italy; Center for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany.
Abstract:
Heart Failure with preserved Ejection Fraction (HFpEF) is nowadays considered a major healthcare issue. According to forecasts two third of all Heart Failure patients will belong to this phenotype by year 2050, overwhelming those affected by Heart Failure with reduced Ejection Fraction (HFrEF). Both epidemiological and mechanistic studies support the concept that HFpEF represents true HF although aggravated by a collection of comorbidities. There is urgent need of improving its phenotyping due to the high degree of disease heterogeneity within HFpEF that lead to the failure of randomized clinical trials in demonstrating a remarkable impact of drugs in improving its morbidity and mortality.
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