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Occurrence and Risk Factors of Uveitis in Juvenile Psoriatic Arthritis: Data From a Population-based Nationwide Study

Karoline Baquet-Walscheid1, Kai Rothaus2, Martina Niewerth3

  • 1K. Baquet-Walscheid, MD, A. Heiligenhaus, MD, Department of Ophthalmology at St. Franziskus Hospital, Muenster, and University of Duisburg-Essen, Faculty of Medicine, Essen; karoline.walscheid@uveitis-zentrum.de.

The Journal of Rheumatology
|January 16, 2022
PubMed

Insights

Juvenile psoriatic arthritis (JPsA) affects 6.6% of patients with uveitis, particularly females and those with early disease onset. Early-onset JPsA increases ocular involvement risk, highlighting distinct clinical differences.

Area of Science:

  • Pediatric Rheumatology
  • Ophthalmology
  • Immunology

Background:

  • Uveitis data in juvenile psoriatic arthritis (JPsA), a subset of juvenile idiopathic arthritis (JIA), are limited.
  • Understanding JPsA-associated uveitis (JPsA-U) prevalence and risk factors is crucial for early detection and management.

Purpose of the Study:

  • To determine the prevalence of uveitis in a cohort of patients with JPsA.
  • To identify clinical and demographic risk factors associated with the development of uveitis in JPsA patients.

Main Methods:

  • Cross-sectional analysis of data from the German National Pediatric Rheumatological Database (2002-2014).
  • Characterization of JPsA-U patients and assessment of risk factors using multivariable analysis.
  • Subgroup analysis focused on patients with early arthritis onset (within 1 year).

Main Results:

  • Uveitis occurred in 6.6% of 1862 JPsA patients.
  • JPsA-U patients were more frequently female, antinuclear antibody (ANA)-positive, younger at onset, and treated with DMARDs.
  • Early-onset JPsA (<5 years) was associated with higher ANA positivity, uveitis incidence, and DMARD use, but less skin disease.

Conclusions:

  • Characteristics of JPsA-U resemble those in other JIA categories like oligoarticular JIA.
  • Children with early-onset JPsA face a significantly higher risk of ocular complications.
  • Distinct clinical differences exist between early-onset and late-onset JPsA patients.
Abstract

Keywords:
epidemiologyjuvenile idiopathic arthritisjuvenile psoriatic arthritispsoriasisuveitis

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