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Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Types of RNA01:23

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Combined Effects of Drugs: Synergism01:27

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
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Antimicrobial Proteins01:23

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
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Antimicrobial Effectiveness01:28

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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Related Experiment Video

Updated: Oct 6, 2025

Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection
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Nanomechanics of Drug-target Interactions and Antibacterial Resistance Detection

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Antisense Agents against Antibiotic-resistant Bacteria.

Javad Nezhadi1,2, Sepehr Taghizadeh2, Ehsaneh Khodadadi3

  • 1Student Research Committee, Tabriz University of Medical Sciences, Tabriz 5166614711, Iran.

Current Pharmaceutical Biotechnology
|January 17, 2022
PubMed
Summary

Antisense oligonucleotides like Peptide Nucleic Acids (PNAs), Phosphorodiamidate Morpholino Oligomers (PPMOs), and Locked Nucleic Acids (LNAs) show promise in combating antibiotic resistance by targeting bacterial genes. Further research into their safety and efficacy is crucial for clinical application.

Keywords:
Antibiotic resistanceLNAsPNAsPPMOsbasesnucleic acids analogs

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Pharmacology

Background:

  • Rising global antibiotic resistance poses a significant public health threat.
  • Antibiotic resistance increases morbidity, mortality, and healthcare costs.
  • Novel therapeutic strategies are urgently needed to address drug-resistant bacteria.

Conclusions:

  • Antisense oligonucleotides represent a promising strategy against antibiotic-resistant bacteria.
  • Further investigation into the safety, toxicity, and pharmacokinetics of these agents is warranted.
  • Clinical translation of antisense therapies requires comprehensive evaluation.