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Related Experiment Video

Updated: Oct 6, 2025

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Defining neuroplasticity.

Giorgio M Innocenti¹

¹Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Handbook of Clinical Neurology

|January 17, 2022

Summary

This summary is machine-generated.

Brain plasticity differs significantly between development and adulthood. While developmental neuroplasticity involves extensive changes, adult neuroplasticity is more limited, primarily affecting synaptic strength and potentially leading to pathologies.

Keywords:

Activity Brain development Cell number Connections Cytoarchitectonic Differentiation Myelin

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Last Updated: Oct 6, 2025

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

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Area of Science:

Neuroscience
Developmental Biology

Background:

Neuroplasticity, the brain's ability to change, varies across lifespan.
Developmental plasticity encompasses neurogenesis, migration, differentiation, and connection formation.
Adult plasticity is generally more restricted, focusing on synaptic modifications.

Purpose of the Study:

To differentiate neuroplasticity during development versus adulthood.
To outline the key processes involved in each stage.
To discuss the implications of neuroplasticity, including pathological outcomes.

Main Methods:

Comparative analysis of developmental and adult brain changes.
Review of established literature on neurogenesis, neuronal migration, differentiation, and myelination.
Examination of synaptic plasticity mechanisms.

Main Results:

Developmental neuroplasticity involves extensive structural and functional brain modifications, including neurogenesis and connection formation.
Adult neuroplasticity is primarily characterized by alterations in synaptic efficacy, with limited regenerative capacity.
Myelination shows plasticity in both developmental and adult stages (rodent models).

Conclusions:

Neuroplasticity undergoes distinct phases from development to adulthood.
While developmental plasticity facilitates learning and function acquisition, adult plasticity is more constrained.
Maladaptive neuroplasticity can contribute to neurological and psychiatric disorders.