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Functional Connectivity Density in the Sensorimotor Area is Associated with Sleep Latency in Patients with Primary

Bin Ji1, Min Dai2, Zhongwei Guo3

  • 1Department of Anesthesiologyand Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People's Republic of China.

Neuropsychiatric Disease and Treatment
|January 17, 2022
PubMed
Abstract

Insights

Patients with primary insomnia (PI) show altered functional connectivity density (FCD) in specific brain regions, including the medial frontal gyrus and supplementary motor area (SMA). These changes correlate with sleep disturbances, suggesting network dysfunction in PI.

Area of Science:

  • Neuroimaging
  • Neuroscience
  • Medical Imaging

Background:

  • Primary insomnia (PI) is a sleep disorder with unclear neurobiological underpinnings.
  • Functional connectivity density (FCD) analysis using resting-state functional MRI (rsfMRI) offers insights into brain network alterations.

Purpose of the Study:

  • To investigate differences in FCD patterns between patients with PI and healthy controls (HCs).
  • To explore the relationship between FCD abnormalities and clinical features of PI.

Main Methods:

  • rsfMRI data were acquired from 32 PI patients and 34 HCs using a 3-Tesla scanner.
  • Whole-brain FCD analysis identified regions with abnormal connectivity in PI patients.
  • Seed-based functional connectivity (FC) analysis was performed on identified abnormal regions.

Main Results:

  • PI patients exhibited decreased FCD in the left medial frontal gyrus and increased FCD in the left supplementary motor area (SMA) compared to HCs.
  • Decreased FC was observed between the left medial frontal gyrus and left fusiform gyrus in PI patients.
  • Increased FC was found between the left SMA and right anterior cingulate gyrus in PI patients.
  • Increased FCD in the left SMA positively correlated with sleep latency in PI patients.

Conclusions:

  • Dysfunctional default-mode network and SMA activity are implicated in the pathophysiology of primary insomnia.
  • rsfMRI-based FCD analysis reveals distinct brain connectivity patterns in PI patients.
Keywords:
functional connectivity densityprimary insomniaresting-state functional magnetic resonance imaging

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