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Updated: Oct 6, 2025

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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Published on: December 10, 2013

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Multimodal immune activation abilities and characteristics of reovirus

So Yeon Kim1, Radhashree Maitra2, Sanjay Goel1,3

  • 1Montefiore Medical Center 1695 Eastchester Road, Bronx, New York 10461, USA.

American Journal of Translational Research
|January 17, 2022
PubMed

Insights

Reovirus, a double-stranded RNA virus, shows anti-tumor properties by inducing oncolysis in cancers with RAS pathway activation. This review explores reovirus

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Reovirus is a non-pathogenic double-stranded RNA virus with demonstrated anti-tumor properties.
  • RAS pathway activation in cancers dysregulates protein kinase receptor (PKR), allowing reovirus replication and oncolysis.
  • Metastatic colorectal cancer (mCRC) treatment lacks benefit from biologic agents in KRAS mutant subtypes.

Purpose of the Study:

  • To review the immune mechanisms of reovirus-induced oncolysis.
  • To present preclinical and clinical data on reovirus (pelareorep) in mCRC.
  • To highlight reovirus as a potential therapeutic for KRAS-mutant mCRC.

Main Methods:

  • Review of preclinical studies on reovirus and cancer models.
  • Analysis of clinical trial data for reovirus in mCRC patients.
  • Examination of reovirus' interactions with the immune system.

Main Results:

  • Reovirus induces oncolysis in RAS-activated cancers by maintaining translational potential.
  • Pelareorep (Reolysin) demonstrates therapeutic potential through multimodal immune mechanisms.
  • Preclinical and clinical data support reovirus' application in mCRC.

Conclusions:

  • Reovirus exhibits significant anti-tumor activity in RAS-activated cancers.
  • Reovirus, particularly pelareorep, offers a promising therapeutic strategy for KRAS-mutant mCRC.
  • Further investigation into reovirus' immune-mediated oncolysis is warranted.
Keywords:
KRASReoviruscolorectal cancerimmune profilelymphocytes

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