Influence of Lower Extremity Deep Venous Thrombosis in Cerebral Infarction on Coagulation Index and Thromboelastogram...

Area of Science:

• Neurology
• Hematology
• Vascular Medicine

Background:

• Cerebral infarction, a brain injury from blocked blood flow, can lead to ischemia and nerve cell death.
• Lower extremity deep venous thrombosis (LEDVT) is a potential complication that may influence coagulation status.
• Understanding these interactions is crucial for managing patients with cerebral infarction.

Purpose of the Study:

• To investigate the impact of LEDVT on coagulation indexes and thromboelastogram (TEG) parameters in patients with cerebral infarction.
• To assess the diagnostic value of TEG and coagulation markers for LEDVT in this patient population.
• To identify independent risk factors for LEDVT in cerebral infarction.

Main Methods:

• Compared coagulation indexes (PT, APTT, TT, FIB) and TEG parameters (R, K, angle, MA) between cerebral infarction patients with and without LEDVT.
• Utilized Receiver Operating Characteristic (ROC) curve analysis to evaluate the diagnostic performance of key parameters.
• Employed logistic regression to determine independent risk factors for LEDVT.

Main Results:

• Patients with cerebral infarction and LEDVT exhibited lower PT, APTT, TT, R, and K values, and higher FIB, angle, and MA values compared to controls.
• ROC analysis indicated diagnostic value for R, K, angle, and MA values (AUCs ranging from 0.713 to 0.819).
• High FIB, angle, and MA were identified as risk factors, while R and K values were protective factors for LEDVT.

Conclusions:

• Cerebral infarction patients with LEDVT demonstrate distinct alterations in coagulation and TEG profiles.
• TEG parameters, particularly angle and MA, show significant diagnostic potential for LEDVT in this cohort.
• FIB, angle, and MA are independent risk factors, whereas R and K values are protective against LEDVT in cerebral infarction.