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Updated: Oct 6, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Omicron: a mysterious variant of concern

A Gowrisankar1, T M C Priyanka1, Santo Banerjee2

  • 1Department of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu 632 014 India.

European Physical Journal Plus
|January 17, 2022
PubMed

Insights

The Omicron variant (B.1.1.529) of SARS-CoV-2 emerged in late 2021. Analysis shows Omicron cases followed existing patterns, despite its unique mutations.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • The Omicron (B.1.1.529) variant of SARS-CoV-2, characterized by 26 spike protein mutations, emerged in November 2021.
  • Its distinct genetic makeup raised concerns regarding virulence and transmission rates, necessitating further research.

Purpose of the Study:

  • To investigate and compare the seven-day moving average of COVID-19 cases in key Omicron-affected countries.
  • To predict the seven-day average of daily positive Omicron cases for December 2021, January 2022, and February 2022.

Main Methods:

  • Comparative analysis of seven-day moving averages of COVID-19 cases.
  • Fractal interpolation method for case prediction.

Main Results:

  • The study compared Omicron variant case trends in Denmark, Germany, India, Netherlands, South Africa, and the UK.
  • Predictions indicated that daily positive case curves maintained their established patterns despite the Omicron variant's emergence.

Conclusions:

  • The Omicron variant's emergence did not significantly alter the overall pattern of daily positive COVID-19 cases in the studied countries.
  • Further research is needed to fully understand the long-term epidemiological impact of the Omicron variant.

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