Discriminative Localized Sparse Approximations for Mass Characterization in Mammograms

The most common form of cancer among women in both developed and developing countries is breast cancer. The early detection and diagnosis of this disease is significant because it may reduce the number of deaths caused by breast cancer and improve the quality of life of those effected. Computer-aided detection (CADe) and computer-aided diagnosis (CADx) methods have shown promise in recent years for aiding in the human expert reading analysis and improving the accuracy and reproducibility of pathology results. One significant application of CADe and CADx is for breast cancer screening using mammograms. In image processing and machine learning research, relevant results have been produced by sparse analysis methods to represent and recognize imaging patterns. However, application of sparse analysis techniques to the biomedical field is challenging, as the objects of interest may be obscured because of contrast limitations or background tissues, and their appearance may change because of anatomical variability. We introduce methods for label-specific and label-consistent dictionary learning to improve the separation of benign breast masses from malignant breast masses in mammograms. We integrated these approaches into our Spatially Localized Ensemble Sparse Analysis (SLESA) methodology. We performed 10- and 30-fold cross validation (CV) experiments on multiple mammography datasets to measure the classification performance of our methodology and compared it to deep learning models and conventional sparse representation. Results from these experiments show the potential of this methodology for separation of malignant from benign masses as a part of a breast cancer screening workflow.