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Related Experiment Video

Updated: Oct 6, 2025

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UV and violet light can Neutralize SARS-CoV-2 Infectivity.

Mara Biasin1, Sergio Strizzi1, Andrea Bianco2

  • 1Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, Milan, Italy.

Journal of Photochemistry and Photobiology
|January 17, 2022
PubMed
Summary
This summary is machine-generated.

Violet light inactivates SARS-CoV-2, though less efficiently than UV-C. Long UV-A and UV-B wavelengths effectively eliminate the virus in patient sputum, explaining lower summer transmission.

Keywords:
Action spectrumDisinfectionFISHInfectivitySARS-CoV-2UV lightVirus replication

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Area of Science:

  • Virology
  • Photobiology
  • Infectious Diseases

Background:

  • The susceptibility of SARS-CoV-2 to ultraviolet (UV) light is crucial for understanding transmission dynamics.
  • Previous studies have indicated UV light's virucidal properties, but specific wavelength effects require further investigation.

Purpose of the Study:

  • To evaluate the virucidal efficacy of discrete UV and violet light wavelengths against SARS-CoV-2.
  • To compare the efficiency of different wavelengths and assess their potential for inactivating the virus in clinical samples.

Main Methods:

  • Infection of SARS-CoV-2 with high titer.
  • Exposure to discrete wavelengths: UV-C (278 nm), UV-B (308 nm), UV-A (366 nm), and violet (405 nm).
  • Viral inactivation quantified using quantitative Polymerase Chain Reaction (qPCR) and fluorescence in situ hybridization (FISH).

Main Results:

  • Violet light (405 nm) achieved a 2-log viral inactivation, 10^4 times less efficient than UV-C (278 nm).
  • UV-A (366 nm) and UV-B (308 nm) wavelengths completely inactivated SARS-CoV-2 viral titers found in patient sputum.
  • RNA viruses appear particularly sensitive to longer UV wavelengths.

Conclusions:

  • SARS-CoV-2 is highly susceptible to UV light, with longer wavelengths like UV-A and UV-B demonstrating significant virucidal effects.
  • The findings suggest a potential mechanism for reduced SARS-CoV-2 incidence during summer months due to solar UV irradiation.
  • This research supports the use of specific light wavelengths for viral disinfection and offers insights into seasonal transmission patterns.