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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

Evaluation of cardiovascular risk in children with solitary functioning kidney

Nadide Melike Sav1, Pelin Kosger2, Betul Can3

  • 1Department of Pediatric Nephrology, Duzce University, Duzce, Turkey. savmelike@gmail.com.

Clinical and Experimental Nephrology
|January 17, 2022
PubMed

Insights

Children with a solitary kidney face increased cardiovascular disease and kidney damage risks. Early monitoring is crucial to prevent significant kidney impairment and manage hypertension.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Health
  • Renal Function

Background:

  • Solitary kidneys can predispose individuals to cardiovascular risks and kidney damage.
  • Understanding these risks in pediatric populations is essential for long-term health outcomes.

Purpose of the Study:

  • To investigate cardiovascular risk and kidney damage markers in children with a solitary functioning kidney.
  • To compare these markers against healthy controls.

Main Methods:

  • Study included 40 children with a solitary kidney and 60 healthy controls.
  • Evaluations included carotid intima-media thickness, ischemia-modified albumin, oxidative stress, and 24-hour ambulatory blood pressure monitoring.

Main Results:

  • Patients with solitary kidneys exhibited higher serum creatinine, urine microalbumin, and lower creatinine clearance.
  • Elevated levels of ischemia-modified albumin, carotid intima-media thickness, aldosterone, plasma renin activity, and blood pressure were observed.
  • A non-dipper blood pressure pattern was noted in the patient group.

Conclusions:

  • Children with a solitary kidney are at a heightened risk for cardiovascular disease.
  • Close monitoring is recommended for these patients to detect and manage potential kidney impairment and cardiovascular complications.
Abstract

Keywords:
24-h ambulatory blood pressure monitoringCardiovascular riskCarotid intima-media thicknessChildrenIschemia-modified albuminSolitary kidney

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