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Marijuana toxicosis in 2 donkeys.

Alyson H Fitzgerald1, Geraldine Magnin2, Ellen Pace3

  • 1Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
|January 17, 2022
PubMed
Summary

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This summary is machine-generated.

Marijuana toxicosis in donkeys is rare but possible with increased cannabis availability. Veterinary diagnostic labs can confirm tetrahydrocannabinol (THC) exposure in affected equines.

Area of Science:

  • Veterinary Toxicology
  • Equine Medicine
  • Pharmacology

Background:

  • Marijuana toxicosis is commonly diagnosed in companion animals.
  • Increased availability of cannabis raises concerns for toxicosis in non-traditional species.
  • Equine practitioners may encounter novel toxicological presentations.

Purpose of the Study:

  • To report suspected marijuana toxicosis in two American Mammoth donkeys.
  • To describe clinical signs and diagnostic findings in equine cannabis ingestion.
  • To highlight the utility of cannabinoid screening in veterinary diagnostics.

Main Methods:

  • Two donkeys (8 and 20 years old) presented with depression and lethargy after consuming cannabis buds.
  • Clinical examinations documented neurologic deficits, colic, tachycardia, tachypnea, and decreased tongue tone.
Keywords:
cannabidiolcannabisequidtoxicology

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  • Plasma and serum samples were analyzed for cannabinoids using high-pressure liquid chromatography coupled with tandem mass spectroscopy (HPLC-MS/MS).

    • Main Results:

    • Tetrahydrocannabinol (THC) was detected in all analyzed samples from both donkeys.
    • Clinical signs, including neurologic deficits and vital sign abnormalities, appeared 24-36 hours post-ingestion.
    • Both donkeys recovered fully within 24 hours of peak clinical effects.

    Conclusions:

    • Cannabis ingestion can cause toxicosis in donkeys, presenting with specific clinical signs.
    • Veterinary diagnostic laboratories equipped with HPLC-MS/MS can confirm THC exposure in equines.
    • Screening for cannabinoids is a valuable tool for equine practitioners suspecting marijuana toxicosis.