Related Experiment Video
Updated: Oct 6, 2025

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
Intensified Hyposensitization Is an Effective Treatment of Postorgasmic Illness Syndrome (POIS)
Joanna Wrotynska-Barczynska1, Edyta Swat2, Anna Berger1
1Department of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.
Introduction:
Postorgasmic illness syndrome (POIS) is an extremely rare urogenital disease which significantly and negatively impacts the functioning and sexual activity.
Aims:
A 34-year-old male presented with POIS symptoms and confirmed the allergic component of the POIS. Intensified immunotherapy with autologous semen was recommended.
Methods:
The treatment lasted 14 months and included 20 visits. Modified and intensified subcutaneous immunotherapy in both forearms significantly shortened the therapy and improved the outcome, with high-tolerance and no adverse effects or hyperactive responses.
Main Outcome Measure:
Improvement in POIS symptoms through the use of intensified immunotherapy with autologous semen.
Results:
The improvement was significant enough to allow for higher sexual activity, and gradual resumption of private and professional activity.
Conclusion:
Intensified immunotherapy with autologous semen seems an effective and safe option for treating patients with suspected immune-allergenic POIS. To the best of our knowledge, this has been the first such intensive and effective allergen-specific immunotherapy of POIS. Wrotynska-Barczynska J, Swat. Swat E, Berger A, et al. Intensified Hyposensitization Is an Effective Treatment of Postorgasmic Illness Syndrome (POIS). Sex Med 2022;10:100474.
Related Concept Videos
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Desensitization and Tachyphylaxis
Allergic Reactions
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Sexually Transmitted Infections
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

