Protective effects of melatonin on changes occurring in the experimental autoimmune encephalomyelitis model of
Begoña María Escribano1, A Muñoz-Jurado2, J Caballero-Villarraso3
1Department of Cell Biology, Physiology and Immunology, Faculty of Veterinary Medicine, Campus of Rabanales, University of Cordoba, Cordoba 14071, Spain; Maimonides Institute for Research in Biomedicine of Cordoba, (IMIBC), Cordoba, Spain.
Background:
Melatonin has been related to the pathophysiology of multiple sclerosis (MS), and its anti-inflammatory and immunomodulatory properties have been proved in numerous neurodegenerative diseases. This study aimed to find out whether a melatonin supplement in MS is able to act as a benefit to its clinical status, i.e. oxidative stress, inflammation and indirect biomarkers of bacterial dysbiosis, lipopolysaccharide (LPS) and LPS-binding protein (LBP), verifying its therapeutic potential and its possible clinical use in patients with MS.
Methods:
The animal MS model, experimental autoimmune encephalomyelitis (EAE), was employed whereby 25 male Dark Agouti rats (5 animals per group) were divided into: a control group (not manipulated); a control+vehicle group; a control+melatonin group; an EAE group; an EAE+melatonin group. Melatonin was administered daily for 51 days, at a dose of 1 mg/kg body weight/i.p., once a day, five days a week.
Results:
The results from the administration of melatonin demonstrated an improvement in clinical status, a diminution in oxidative stress and inflammation, as well as in bacterial dysbiosis.
Conclusion:
Melatonin could play an effective role against MS, either alone or as a therapy combined with traditional agents.
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