[Neurodevelopmental disorders in children and the possibilities of their pharmacotherapy]

N N Zavadenko1, N Yu Suvorinova1, A N Zavadenko1

  • 1Pirogov Russian National Research Medical University, Moscow, Russia.

Insights

This review examines "Tenoten for children," a medication for neurodevelopmental disorders (NDD) like ADHD and learning disabilities. Clinical trials suggest potential benefits for affected children.

Area of Science:

  • Neuroscience
  • Pediatrics
  • Developmental Psychology

Background:

  • Neurodevelopmental disorders (NDD) impact cognitive, communication, behavioral, and motor skills due to neuroontogenesis abnormalities.
  • NDD encompass conditions like ADHD, dyslexia, dysgraphia, and dyscalculia, often co-occurring with anxiety disorders in children.
  • These disorders have a multifactorial origin, involving genetic factors and early-life brain damage, necessitating early intervention during critical developmental periods.

Purpose of the Study:

  • To review clinical trial results for "Tenoten for children."
  • To evaluate the efficacy of this pharmacotherapy in treating ADHD, specific learning disorders, anxiety disorders, and consequences of perinatal brain damage in children.

Main Methods:

  • Review of published results from multicenter, double-blind, placebo-controlled, randomized clinical trials.
  • Focus on pharmacotherapy trials involving "Tenoten for children."

Main Results:

  • The review synthesizes findings from clinical trials on "Tenoten for children."
  • Results pertain to the medication's effects on ADHD, specific learning disorders, anxiety disorders, and perinatal brain injury consequences.

Conclusions:

  • Early intervention is crucial for NDD, leveraging the brain's plasticity.
  • The reviewed trials provide insights into the potential therapeutic role of "Tenoten for children" in managing NDD symptoms and related conditions.

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
17
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
114
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
12
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
11
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
285
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
10