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Updated: Oct 6, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
Published on: March 2, 2018
[Neurodevelopmental disorders in children and the possibilities of their pharmacotherapy]
N N Zavadenko1, N Yu Suvorinova1, A N Zavadenko1
1Pirogov Russian National Research Medical University, Moscow, Russia.
Insights
This review examines "Tenoten for children," a medication for neurodevelopmental disorders (NDD) like ADHD and learning disabilities. Clinical trials suggest potential benefits for affected children.
Area of Science:
- Neuroscience
- Pediatrics
- Developmental Psychology
Background:
- Neurodevelopmental disorders (NDD) impact cognitive, communication, behavioral, and motor skills due to neuroontogenesis abnormalities.
- NDD encompass conditions like ADHD, dyslexia, dysgraphia, and dyscalculia, often co-occurring with anxiety disorders in children.
- These disorders have a multifactorial origin, involving genetic factors and early-life brain damage, necessitating early intervention during critical developmental periods.
Purpose of the Study:
- To review clinical trial results for "Tenoten for children."
- To evaluate the efficacy of this pharmacotherapy in treating ADHD, specific learning disorders, anxiety disorders, and consequences of perinatal brain damage in children.
Main Methods:
- Review of published results from multicenter, double-blind, placebo-controlled, randomized clinical trials.
- Focus on pharmacotherapy trials involving "Tenoten for children."
Main Results:
- The review synthesizes findings from clinical trials on "Tenoten for children."
- Results pertain to the medication's effects on ADHD, specific learning disorders, anxiety disorders, and perinatal brain injury consequences.
Conclusions:
- Early intervention is crucial for NDD, leveraging the brain's plasticity.
- The reviewed trials provide insights into the potential therapeutic role of "Tenoten for children" in managing NDD symptoms and related conditions.
Abstract:
Neurodevelopmental disorders (NDD) are characterized by disturbances of the formation of cognitive functions, communication skills, behavior characteristics and/or motor skills, which are caused by abnormalities in the course of the processes of neuroontogenesis. In the clinical practice of a pediatric neurologist and pediatrician, a significant part consists of patients with NDD without a general decrease in intelligence, primarily with speech development disorders, attention deficit hyperactivity disorder (ADHD), specific learning disorders (dyslexia, dysgraphia, dyscalculia). NDD represent a heterogeneous group of diseases, having multifactorial origin and a neurobiological nature, which are caused by genetic mechanisms and early (perinatal) brain damage. Among children with NDD, there is a higher occurrence of anxiety disorders compared to their peers. With NDD, early intervention is indicated, and its positive effect is possible during the period when the brain is most plastic and capable of changes. The published results of multicenter, double-blind, placebo-controlled, randomized clinical trials of pharmacotherapy with the medication "Tenoten for children" for ADHD, specific learning disorders, anxiety disorders and the consequences of perinatal damage to the central nervous system are reviewed.
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