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Neutrophils in chronic inflammatory diseases
Andrea Herrero-Cervera1, Oliver Soehnlein2,3, Ellinor Kenne3
1Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, Westfälische Wilhelms-Universität Münster, Münster, Germany. herreroc@uni-muenster.de.
Cellular & Molecular Immunology
|January 18, 2022
Summary
Neutrophils, key immune cells, play a complex role in chronic inflammation, impacting aging and diseases like atherosclerosis. Understanding their dual function offers new therapeutic avenues.
Area of Science:
- Immunology
- Pathophysiology
- Cell Biology
Background:
- Chronic inflammation affects millions globally, particularly the elderly.
- Neutrophils are primary responders in acute inflammation but their chronic role is unclear.
- Neutrophils can be detrimental, causing tissue damage, or beneficial in chronic inflammatory conditions.
Purpose of the Study:
- To review the multifaceted role of neutrophils in chronic inflammation.
- To explore neutrophil interactions with other cells in chronic disease.
- To discuss potential therapeutic strategies targeting neutrophils.
Main Methods:
- Literature review of existing research on neutrophils in chronic inflammation.
- Analysis of neutrophil involvement in specific chronic diseases.
- Synthesis of current understanding and future research directions.
Main Results:
- Neutrophils exhibit a dual role in chronic inflammation, contributing to both disease progression and resolution.
- Emerging evidence links neutrophils to atherosclerosis, diabetes mellitus, NAFLD, and autoimmune disorders.
- Cell-cell interactions involving neutrophils are critical in chronic inflammatory settings.
Conclusions:
- Neutrophils are significant contributors to various chronic inflammatory diseases.
- Targeting neutrophil functions presents promising therapeutic opportunities.
- Further research is needed to fully elucidate neutrophil mechanisms in chronic inflammation.
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