Irisin: circulating levels in serum and its relation to gonadal axis

Area of Science:

• Endocrinology
• Reproductive Biology
• Metabolic Health

Background:

• Irisin is an exercise-induced myokine/adipokine influencing white adipose tissue browning and metabolic health.
• Circulating irisin levels correlate with exercise, obesity, diet, and various diseases.
• Previous research suggests irisin's involvement in folliculogenesis and fertility, with conflicting results in Polycystic Ovary Syndrome (PCOS).

Purpose of the Study:

• To review the current understanding of irisin physiology and its role in the gonadal axis.
• To examine irisin levels in PCOS and their relationship with BMI, insulin resistance, and hyperandrogenism.
• To explore irisin's novel effects on reproduction and fertility through animal and in vitro studies.

Main Methods:

• Literature review of irisin physiology, secretion, and regulation.
• Analysis of studies on irisin levels in PCOS, considering BMI, insulin resistance, and hyperandrogenism.
• Synthesis of findings from animal interventional studies and in vitro experiments on irisin and the gonadal axis.

Main Results:

• Irisin's physiological roles and regulatory mechanisms are detailed.
• Associations between irisin, PCOS, BMI, insulin resistance, and hyperandrogenism are explored.
• Evidence from experimental studies suggests novel effects of irisin on reproductive functions and fertility.

Conclusions:

• Irisin plays a significant role in the gonadal axis, impacting reproductive health.
• Further research is warranted to elucidate irisin's therapeutic potential in metabolic and reproductive disorders.
• Irisin emerges as a potential key player in fertility and reproductive disease management.