Multi-feature Fusion Method Based on Linear Neighborhood Propagation Predict Plant LncRNA-Protein Interactions

Long non-coding RNAs (lncRNAs) have attracted extensive attention due to their important roles in various biological processes, among which lncRNA-protein interaction plays an important regulatory role in plant immunity and life activities. Laboratory methods are time consuming and labor-intensive, so that many computational methods have gradually emerged as auxiliary tools to assist relevant research. However, there are relatively few methods to predict lncRNA-protein interaction of plant. Due to the lack of experimentally verified interactions data, there is an imbalance between known and unknown interaction samples in plant data sets. In this study, a multi-feature fusion method based on linear neighborhood propagation is developed to predict plant unobserved lncRNA-protein interaction pairs through known interaction pairs, called MPLPLNP. The linear neighborhood similarity of the feature space is calculated and the results are predicted by label propagation. Meanwhile, multiple feature training is integrated to better explore the potential interaction information in the data. The experimental results show that the proposed multi-feature fusion method can improve the performance of the model, and is superior to other state-of-the-art approaches. Moreover, the proposed approach has better performance and generalization ability on various plant datasets, which is expected to facilitate the related research of plant molecular biology.