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Updated: Oct 6, 2025
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Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
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Refractory ulcerative colitis stabilized by interval washed microbiota transplantation: less is more
Yun Wang1,2, Bota Cui1,2, Faming Zhang1,2
1Medical Center for Digestive Diseases, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Current Medical Research and Opinion
|January 18, 2022
Summary
Washed microbiota transplantation (WMT) offers a promising long-term treatment for ulcerative colitis (UC). This novel approach, delivered via colonic transendoscopic enteral tubing (TET), achieved sustained remission in a refractory UC patient.
Area of Science:
- Gastroenterology
- Microbiology
- Immunology
Background:
- Ulcerative colitis (UC) is a chronic autoimmune disorder with a relapsing-remitting course.
- The gut microbiota plays a significant role in UC pathogenesis.
- Fecal microbiota transplantation (FMT) is an emerging therapy for refractory UC.
Purpose of the Study:
- To evaluate the efficacy of novel washed microbiota transplantation (WMT) delivery methods for refractory ulcerative colitis (UC).
- To explore the potential of repeated interval WMT as a long-term management strategy for UC.
Main Methods:
- A patient with refractory UC received two FMT strategies: daily fresh FMT via percutaneous endoscopic cecostomy (PEC) tube for 60 days, followed by WMT every 3-35 months via colonic transendoscopic enteral tubing (TET) or gastroscopy.
- WMT utilized an automatic purification and washing system.
Main Results:
- The patient showed effective response to both fresh FMT and WMT strategies.
- Repeated interval WMTs successfully induced long-term clinical remission in the patient.
Conclusions:
- Repeated interval WMT is a viable long-term treatment strategy for refractory UC.
- Further research into optimizing WMT frequency, interval, and delivery is warranted.
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