Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

731
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
731
Chemotaxis in E. coli01:27

Chemotaxis in E. coli

165
Chemotaxis in Escherichia coli is a sensory-driven motility mechanism that enables bacteria to navigate chemical gradients, moving toward beneficial environments while avoiding harmful conditions. This process relies on a signal transduction system integrating external chemical cues with flagellar motor control.Chemoreceptors and Signal DetectionE. coli detects chemical gradients through methyl-accepting chemotaxis proteins (MCPs), which are membrane-bound chemoreceptors that sense attractants...
165
Chromatin Immunoprecipitation- ChIP02:36

Chromatin Immunoprecipitation- ChIP

11.5K
Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
11.5K
Synthesis of Phosphatidylcholine in the ER Membrane01:27

Synthesis of Phosphatidylcholine in the ER Membrane

3.4K
The ER synthesizes lipids for building cell membranes and performing cellular functions such as energy storage and signaling. The lipid synthesis machinery embedded in the ER membrane primarily collects all reactants from the cytosol. Following synthesis, the secretory pathway and the ER contact sites distribute these lipids to other cellular organelles. Additionally, the energy-rich triacylglycerides are transported from the ER via lipid droplets.
The major components of all eukaryotic cell...
3.4K
Regulation of Metabolism01:19

Regulation of Metabolism

10.2K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
10.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice.

Journal of cachexia, sarcopenia and muscle·2026
Same author

Targeted, receptor-mediated delivery of a masked d-amino acid cell-penetrating peptide for cell-specific phototoxicity.

The FEBS journal·2026
Same author

NanoBRET-based detection of ligand-receptor interactions at the neuropeptide FF receptor 1.

RSC advances·2026
Same author

Fatty acid regulation of feeding in <i>Caenorhabditis</i> elegans reveals the potential ancestral origin of a GLP-1-like multiagonist signaling system.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Modulating food intake by nasal application of peptides targeting melanocortin 4 receptor and ghrelin receptor systems.

Brain communications·2026
Same author

The pathway-independent positive allosteric modulator C1 allows for the identification of active Y<sub>4</sub> receptor relevant positions.

Cellular and molecular life sciences : CMLS·2026
Same journal

Neuronal membrane organization by the submembranous spectrin-ankyrin scaffold: evolution, specialization and disease.

Biological chemistry·2026
Same journal

Golgi-associated membrane scaffolds: roles in health and disease.

Biological chemistry·2026
Same journal

Mechanistic insights on spatiotemporal control of Ras-signaling.

Biological chemistry·2026
Same journal

Cysteine cathepsin proteases in apicomplexan parasites.

Biological chemistry·2026
Same journal

Electron donating and withdrawing groups affect the antioxidant activity of 4'-aminochalcones on gentamicin-induced kidney cell injury.

Biological chemistry·2026
Same journal

CNKSR2 scaffold function in the mammalian nervous system.

Biological chemistry·2026
See all related articles

Related Experiment Video

Updated: Oct 6, 2025

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

20.3K

Chemerin - exploring a versatile adipokine.

Tobias F Fischer1, Annette G Beck-Sickinger1

  • 1Institute of Biochemistry, University of Leipzig, Brüderstraße 34, D-04103 Leipzig, Germany.

Biological Chemistry
|January 18, 2022
PubMed
Summary
This summary is machine-generated.

Chemerin, an immune protein and adipokine, activates immune responses and regulates energy. It binds three receptors (GPCRs), influencing signaling pathways relevant to obesity and cancer therapies.

Keywords:
adipose tissuecytokineimmunityinflammationobesity

More Related Videos

Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting
08:28

Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting

Published on: June 30, 2017

9.5K
Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
08:30

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

9.4K

Related Experiment Videos

Last Updated: Oct 6, 2025

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

20.3K
Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting
08:28

Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting

Published on: June 30, 2017

9.5K
Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots
08:30

Encapsulation Thermogenic Preadipocytes for Transplantation into Adipose Tissue Depots

Published on: June 2, 2015

9.4K

Area of Science:

  • Biochemistry
  • Immunology
  • Endocrinology

Background:

  • Chemerin is a protein involved in immune response and energy balance.
  • It requires activation by proteases to become biologically active.
  • Chemerin interacts with three G protein-coupled receptors (GPCRs): CMKLR1, GPR1, and CCRL2.

Purpose of the Study:

  • To review the expression, activation, and receptor binding of chemerin.
  • To summarize the role of chemerin in cancer and obesity-related diseases.
  • To discuss recent advancements in therapeutic strategies targeting the chemerin system.

Main Methods:

  • Literature review of chemerin's biological functions and receptor interactions.
  • Analysis of chemerin's involvement in various disease states.
  • Examination of current therapeutic approaches targeting the chemerin pathway.

Main Results:

  • Chemerin's interaction with CMKLR1, GPR1, and CCRL2 varies in signaling outcomes.
  • GPR1 functions as a decoy receptor due to constitutive endocytosis.
  • Chemerin plays a significant role in the pathogenesis of cancer and obesity-related conditions.

Conclusions:

  • The chemerin system presents a promising target for novel therapeutic interventions.
  • Understanding chemerin-receptor interactions is crucial for developing effective treatments.
  • Further research into chemerin's multifaceted roles can unlock new treatment strategies for complex diseases.