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In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
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Leishmania and its relationships with bacteria
Pedro H Gallo-Francisco1, Marcelo Brocchi2, Selma Giorgio1
1Department of Animal Biology, Biology Institute, State University of Campinas, Campinas SP, 13083-862, Brazil.
Future Microbiology
|January 18, 2022
Summary
This review explores bacterial co-infections in leishmaniasis, a neglected zoonotic disease. It examines how these interactions impact hosts and the ecological dynamics between Leishmania parasites and bacteria.
Area of Science:
- Parasitology
- Infectious Diseases
- Microbiology
Background:
- Leishmaniasis is a significant global public health concern, classified as a neglected zoonotic disease.
- Secondary bacterial infections complicate leishmaniasis, worsening host conditions.
- Various *Leishmania* species cause distinct disease manifestations.
Purpose of the Study:
- To review the prevalence and significance of bacterial co-infections in leishmaniasis.
- To analyze the ecological relationship between *Leishmania* and co-infecting bacteria.
- To investigate the 'facilitation phenomenon' in *Leishmania*-bacteria interactions and their host consequences.
Main Methods:
- Literature review of studies on bacterial co-infections in leishmaniasis.
- Analysis of ecological interactions and the facilitation phenomenon.
- Examination of the impact of co-infections on host health.
Main Results:
- Bacterial co-infections are a common complication in leishmaniasis.
- The interaction between *Leishmania* and bacteria can be mutually beneficial (facilitation).
- Co-infections significantly alter disease progression and host outcomes.
Conclusions:
- Understanding bacterial co-infections is crucial for managing leishmaniasis.
- The facilitation phenomenon plays a key role in the pathogenesis of leishmaniasis.
- Further research into these complex interactions is needed for improved therapeutic strategies.
Keywords:
bacterial co-infectionleishmaniasisopportunistic bacteriasecondary infectionsymbiotic facilitationMore Related Videos
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