Related Experiment Video
Updated: Oct 6, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
Alcohol-Attributable Burden of Disease in the Americas in 2000 and 2016
Bethany R Chrystoja1, Maristela Monteiro2, Jürgen Rehm1,3,4,5,6,7,8
1Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Objective:
The purpose of this study was to estimate the alcohol-attributable disease burden in the Americas in 2000 and 2016.
Method:
The alcohol-attributable disease burden was estimated using a comparative risk assessment approach. Alcohol exposure and relative risk estimates were obtained from systematic reviews and meta-analyses. Burden of disease estimates were obtained from the World Health Organization's Global Health Estimates.
Results:
In 2016, 372,000 deaths and 18.9 million disability-adjusted life years (DALYs) lost were because of alcohol use in the Americas. The age-standardized rates (ASRs) of alcohol-attributable deaths ranged from 16.2 to 54.3 deaths per 100,000 in Jamaica and Guyana, respectively. From 2000 to 2016, ASRs decreased by 12.8% for alcohol-attributable deaths and decreased by 10.8% for alcohol-attributable DALYs lost. The decreases in ASRs for alcohol-attributable deaths and alcohol-attributable DALYs lost were less than the relative decreases in the ASRs for all deaths (18.7%) and all DALYs lost (15.7%). ASRs for alcohol-attributable deaths increased in eight countries.
Conclusions:
Alcohol continues to be a leading risk factor for the burden of disease in the Americas, with the degree and composition of this burden varying between countries. Despite a general reduction across the region, in many countries the rising alcohol-attributable disease burden constitutes a major public health challenge.
More Related Videos
08:45Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
Published on: November 8, 2024
07:31Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
Related Concept Videos
Hypothesis Test for Test of Independence
H0: The two variables (factors)...
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
CNS Depressants: Alcohol and Nicotine
Stress Prevention and Stress Management Techniques IV
Alcohols from Carbonyl Compounds: Reduction
Catalytic hydrogenation is similar to the reduction of an alkene or alkyne by adding H2 across the pi bond in the presence of transition metal catalysts like Raney Ni, Pd–C, Pt, or Ru. Aldehydes and ketones can be reduced by this method, often under mild to moderate heat (25–100°C) and...