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In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

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Related Experiment Video

Updated: Oct 6, 2025

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Fertility Preservation in Patients with Severe Ovarian Dysfunction

Published on: March 25, 2021

Preserving Oocytes in Oncofertility†.

Maria McClam¹, Shuo Xiao²

¹Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.

Biology of Reproduction

|January 18, 2022

Summary

This summary is machine-generated.

Cancer treatments can harm ovaries, impacting fertility in young women. Oncofertility offers fertility preservation options like oocyte cryopreservation to protect reproductive potential after cancer recovery.

Keywords:

cancer fertility preservation follicle oncofertility oocyte ovary

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Author Spotlight: Advancing Fertility Preservation in Young Female Cancer Patients Through Ovarian Tissue Vitrification and In Vitro Follicular Growth

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Published on: August 9, 2024

Area of Science:

Reproductive Medicine
Oncology
Genetics

Background:

Cancer survival rates are increasing, making long-term quality of life and treatment side effects crucial.
Ovarian toxicity from chemotherapy and irradiation poses risks like premature ovarian failure and infertility in female cancer patients.
Oncofertility addresses fertility preservation needs for cancer survivors.

Purpose of the Study:

To review current oocyte preservation techniques within the field of oncofertility.
To summarize available options for maintaining female fertility in young cancer patients.

Main Methods:

Comprehensive review of peer-reviewed literature on oocyte preservation.
Detailed description of various fertility preservation strategies.

Main Results:

Oocyte and embryo cryopreservation are key methods.
Ovarian suppression, tissue cryopreservation, in vitro maturation, ovarian transposition, and adjuvant therapies are discussed.
Current guidelines and practices for female fertility preservation are examined.

Conclusions:

Preserving oocyte quality and quantity is vital for female fertility post-cancer.
Oncofertility offers multiple strategies to safeguard reproductive capabilities.
Effective fertility preservation is essential for young female cancer survivors.