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Updated: Oct 6, 2025

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New Developments in Topical Acne Therapy.

Lara Drake1,2, Sophia Reyes-Hadsall1,3, John S Barbieri1,4

  • 1Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA, 02115, USA.

American Journal of Clinical Dermatology
|January 18, 2022
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Summary
This summary is machine-generated.

New topical acne treatments offer improved efficacy and tolerability. This review covers recently approved options and those in clinical trials, focusing on novel retinoids and antiandrogens for better acne vulgaris management.

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Area of Science:

  • Dermatology and Cutaneous Medicine
  • Inflammatory Skin Diseases
  • Pharmacology and Therapeutics

Background:

  • Acne vulgaris is a prevalent, chronic inflammatory skin condition with complex causes.
  • Existing acne treatments face limitations in efficacy, patient tolerability, and cost.
  • There is an ongoing need for advanced therapeutic options for acne vulgaris.

Purpose of the Study:

  • To review recently approved topical acne treatments.
  • To discuss novel acne treatments currently in clinical trials.
  • To highlight advancements in managing acne vulgaris.

Main Methods:

  • Review of recently approved topical acne medications.
  • Analysis of agents in late-stage clinical development for acne treatment.
  • Examination of novel formulations and first-in-class compounds.

Main Results:

  • Novel formulations of tretinoin, tazarotene, and minocycline offer product improvements.
  • Trifarotene, a new retinoid, shows enhanced tolerability over existing options.
  • Clascoterone, a topical antiandrogen, targets the hormonal basis of acne.

Conclusions:

  • Emerging topical agents, including novel retinoids and antiandrogens, represent significant advancements in acne treatment.
  • The pipeline includes agents with bactericidal and anti-sebum properties.
  • Further comparative studies are essential to establish optimal, cost-effective treatment strategies for acne vulgaris.