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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Psoriasis-like Skin Inflammation

Yuli Zhang1,2, Jianjun Yan1, Zhengjun Li1

  • 1Department of Dermatology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
|January 18, 2022
PubMed

Insights

Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSCs-Exo) show therapeutic potential for psoriasis. These exosomes reduce skin inflammation, epidermal proliferation, and key inflammatory markers like IL-17 and IL-23 in preclinical models.

Area of Science:

  • Immunology
  • Dermatology
  • Regenerative Medicine

Background:

  • Mesenchymal stem cells (MSCs) exhibit immunomodulatory properties beneficial for inflammatory conditions like psoriasis.
  • The specific role of MSC-derived exosomes (MSCs-Exo) in psoriasis-like skin inflammation requires further elucidation.

Purpose of the Study:

  • To investigate the regulatory function of MSCs-Exo in psoriasis-like skin inflammation.
  • To determine the therapeutic potential of human umbilical cord MSCs-Exo (hucMSCs-Exo) in a preclinical psoriasis model.

Main Methods:

  • Subcutaneous injection of hucMSCs-Exo in imiquimod (IMQ)-induced psoriasis-like mouse model.
  • Assessment of epidermal proliferation and Psoriasis Area and Severity Index (PASI) scores.
  • Analysis of inflammatory markers (IL-17, IL-23, CCL20) and STAT3 phosphorylation in skin tissues and HaCaT cells.
  • In vitro evaluation of dendritic cell (DC) maturation and activation upon co-culture with hucMSCs-Exo.

Main Results:

  • hucMSCs-Exo significantly suppressed epidermal proliferation and reduced PASI scores in IMQ-induced mice.
  • hucMSCs-Exo decreased the expression of IL-17, IL-23, and CCL20, and inhibited STAT3 phosphorylation.
  • In vitro, hucMSCs-Exo suppressed DC maturation and activation, accompanied by reduced IL-23 expression.

Conclusions:

  • hucMSCs-Exo effectively ameliorate psoriasis-like skin inflammation by modulating IL-23 and IL-17 expression.
  • Inhibition of DC maturation and activation by hucMSCs-Exo contributes to their therapeutic effect.
  • hucMSCs-Exo represent a promising therapeutic strategy for psoriasis leveraging their immunomodulatory capabilities.
Keywords:
dendritic cellsexosomesinflammationkeratinocytespsoriasis

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