Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

489
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
489
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

43
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
43
Analgesia and Pain Management01:25

Analgesia and Pain Management

902
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
902
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

438
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
438

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematic Review of Leiomyomas of the Upper Extremity: Evaluating the Role of Ultrasound in Preoperative Diagnosis.

Hand (New York, N.Y.)·2026
Same author

Companian Editorial Letter.

Journal of hand and microsurgery·2026
Same author

Hand and Upper-Extremity Surgeons Are Poised to Lead Efforts in Promoting Sustainability in the Operating Room.

The Journal of hand surgery·2025
Same author

A Practical Guide to Local Anesthetic Options for Wide-awake Hand Surgery (WALANT): A Laboratory-based Experimental Study.

Plastic and reconstructive surgery. Global open·2025
Same author

Tips to Help Hand Surgeons and Therapists Do Their Own Ultrasound Examinations.

Plastic and reconstructive surgery. Global open·2025
Same author

Surgeons Can Decrease the Pain of WALANT Local Anesthesia Injection if They Ask for Patient Feedback.

Plastic surgery (Oakville, Ont.)·2025

Related Experiment Video

Updated: Oct 6, 2025

Metacarpal Small Incision for Carpal Tunnel Syndrome
04:08

Metacarpal Small Incision for Carpal Tunnel Syndrome

Published on: April 5, 2024

704

Time to Stop Routinely Prescribing Opiates after Carpal Tunnel Release.

Donald H Lalonde1, Janice F Lalonde1, Joy C MacDermid1

  • 1From the Division of Plastic Surgery, Dalhousie University; Dr. Donald H. Lalonde Professional Corporation; Department of Physical Therapy and Surgery, Western University; Section of Plastic Surgery, Department of Surgery, The University of Michigan Health System; Department of Plastic and Orthopedic Surgery, Western University; Department of Orthopaedics, Virginia Tech Carilion School of Medicine; Sanford Orthopedic and Sports Medicine, Sanford School of Medicine, University of South Dakota; and Department of Plastic Surgery, McGill University.

Plastic and Reconstructive Surgery
|January 18, 2022
PubMed
Summary

Over-the-counter pain relief is as effective as opioids for carpal tunnel surgery. This study suggests surgeons should stop routine narcotic prescriptions for post-surgery pain management.

More Related Videos

Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
05:18

Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome

Published on: May 26, 2023

1.6K
Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata
07:58

Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata

Published on: November 23, 2017

7.8K

Related Experiment Videos

Last Updated: Oct 6, 2025

Metacarpal Small Incision for Carpal Tunnel Syndrome
04:08

Metacarpal Small Incision for Carpal Tunnel Syndrome

Published on: April 5, 2024

704
Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
05:18

Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome

Published on: May 26, 2023

1.6K
Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata
07:58

Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata

Published on: November 23, 2017

7.8K

Area of Science:

  • Orthopedic Surgery
  • Pain Management
  • Pharmacology

Background:

  • Routine narcotic prescriptions for postoperative pain after carpal tunnel surgery can lead to persistent opioid use.
  • A multicenter trial was conducted to compare over-the-counter (OTC) medications with opioid pain control.

Purpose of the Study:

  • To investigate if OTC medications are inferior to opioid pain control for patients undergoing carpal tunnel release.
  • To provide evidence-based recommendations for postoperative pain management strategies.

Main Methods:

  • A double-blind, multicenter trial involving 347 patients undergoing carpal tunnel release.
  • Patients were randomized to receive either hydrocodone/acetaminophen (opioid) or ibuprofen/acetaminophen (OTC).
  • Primary outcomes included the Numeric Pain Rating Scale and Patient-Reported Outcome Measurement Information System (PROMIS) Pain Interference T-score.

Main Results:

  • No significant differences were observed in pain scores or patient satisfaction between the opioid and OTC groups.
  • Opioid patients reported slightly higher pain on the night of surgery and more pain interference on the day of surgery.
  • Patient nationality and sex did not significantly impact pain scores.

Conclusions:

  • Over-the-counter acetaminophen/ibuprofen provides non-inferior pain management compared to opioids after carpal tunnel surgery.
  • Evidence supports U.S. and Canadian surgeons discontinuing routine narcotic prescriptions for eligible post-carpal tunnel surgery patients.