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Related Experiment Videos

Pain in Parkinson's disease.

C G Goetz1, C M Tanner, M Levy

  • 1Department of Neurological Sciences, Rush-Presbyterian-St. Lukes Medical Center, Rush Medical College, Chicago, Illinois.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 1, 1986
PubMed
Summary

Nearly half of Parkinson's disease (PD) patients experience pain, often linked to peak motor fluctuations. This pain, frequently musculoskeletal, affects younger patients but not necessarily those with greater motor impairment.

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Area of Science:

  • Neurology
  • Pain Medicine
  • Movement Disorders

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder affecting movement.
  • Pain is a common but often under-recognized non-motor symptom in PD.
  • Understanding pain characteristics and triggers is crucial for patient management.

Purpose of the Study:

  • To determine the prevalence and nature of pain in Parkinson's disease patients.
  • To investigate the relationship between pain and motor fluctuations in PD.
  • To identify specific pain types and their timing relative to motor disability.

Main Methods:

  • Cross-sectional study of 95 Parkinson's disease outpatients.
  • Pain assessment including type, frequency, and attribution to PD.

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  • Correlation analysis with objective motor scores and motor fluctuation status.

    • Main Results:

    • 46% of PD patients reported pain attributed to their condition.
    • Musculoskeletal, dystonic, and joint pain were the most common types.
    • Pain episodes, particularly cramps, coincided with maximal parkinsonian motor disability.
    • Patients with pain were younger but showed no significant difference in objective motor disability scores.

    Conclusions:

    • Pain is a prevalent symptom in Parkinson's disease, affecting nearly half of outpatients.
    • Pain is strongly associated with periods of maximal motor disability, suggesting a link to dopaminergic fluctuations.
    • Targeted pain management strategies, especially during "off" periods, may improve quality of life for PD patients.