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Related Experiment Videos

Parkinsonism and acquired hydrocephalus.

J Jankovic1, M Newmark, P Peter

  • 1Department of Neurology, Baylor College of Medicine, Houston, TX 77030.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 1, 1986
PubMed
Summary

A rare case of pediatric parkinsonism linked to hydrocephalus was observed. Surgical relief of intracranial pressure led to symptom resolution, highlighting a novel association.

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Area of Science:

  • Neurology
  • Pediatric Neurology
  • Neurosurgery

Background:

  • Hydrocephalus, a condition of excess cerebrospinal fluid, can cause increased intracranial pressure.
  • Aqueductal stenosis, narrowing of the cerebral aqueduct, is a common cause of obstructive hydrocephalus.
  • Parkinsonism, a neurological disorder characterized by tremors and rigidity, is typically associated with adult-onset neurodegenerative conditions.

Observation:

  • A 14-year-old female presented with left hemiparkinsonism as the initial symptom.
  • This parkinsonism was directly correlated with elevated intracranial pressure.
  • The patient's symptoms resolved following the insertion of a ventriculo-peritoneal shunt to alleviate the pressure.

Findings:

  • This case represents the first documented instance of parkinsonism associated with hydrocephalus due to non-neoplastic aqueductal stenosis.
  • The resolution of parkinsonism after cerebrospinal fluid diversion suggests a direct link between intracranial pressure and the neurological symptoms.
  • The findings challenge the conventional understanding of parkinsonism as solely a neurodegenerative disorder.

Implications:

  • This case expands the differential diagnosis for pediatric parkinsonism, including treatable causes related to intracranial pressure.
  • It underscores the importance of investigating intracranial pressure in pediatric patients presenting with parkinsonian features.
  • Further research may elucidate the mechanisms by which elevated intracranial pressure induces parkinsonism and its reversibility.

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