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Updated: Oct 6, 2025
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Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device
Published on: August 30, 2016
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Outlook on next-generation probiotics from the human gut
Francesca De Filippis1,2, Alessia Esposito1, Danilo Ercolini3,4
1Department of Agricultural Sciences, University of Naples Federico II, Naples, Italy.
Cellular and Molecular Life Sciences : CMLS
|January 19, 2022
Summary
Next-generation probiotics (NGPs) from the gut microbiome offer potential health benefits beyond current options. Research is ongoing to overcome challenges in their cultivation, storage, and clinical validation for wider use.
Area of Science:
- Microbiology
- Gastroenterology
- Biotechnology
Background:
- Current probiotics utilize a limited range of microbial species.
- The gut microbiome is a rich source of potentially beneficial microbes.
- Gut microbial commensals play a crucial role in human health.
Purpose of the Study:
- To review recent evidence on next-generation probiotics (NGPs).
- To identify novel microbial strains from the gut for probiotic development.
- To discuss challenges hindering the widespread application of NGPs.
Main Methods:
- Literature review of recent studies on NGPs.
- Analysis of research focusing on identifying and testing novel gut microbial strains.
- Examination of challenges in cultivation, storage, and regulatory approval.
Main Results:
- NGPs show promise for preventing and treating chronic diseases.
- Human subject studies for NGPs are currently limited.
- Regulatory approval for NGPs is infrequent.
Conclusions:
- The gut microbiome is a key reservoir for discovering next-generation probiotics.
- Further research is needed to address cultivation, storage, and clinical efficacy of NGPs.
- Overcoming current limitations is essential for the market implementation of NGPs.
Keywords:
Akkermansia muciniphilaFaecalibacterium prausnitziiGut microbiomeLive biotherapeuticsNext-generation probioticsPrevotella copriMore Related Videos
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