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Bacopa monnieri for Disorders Affecting Brain: Current Perspectives.
Adithya Vinod1, Sankaran Sathianarayanan2, Anju Elizabath Babu1
1Amrita School of Pharmacy, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682 041, Kerala, India.
Bacopa monnieri shows therapeutic potential for brain disorders like Alzheimer's and Parkinson's. Further research and novel formulations are needed for clinical translation.
Area of Science:
- Neuroscience
- Pharmacology
- Herbal Medicine
Background:
- Bacopa monnieri (BM) possesses significant therapeutic potential for neurological disorders.
- This review focuses on BM's role in Alzheimer's disease, Parkinson's disease, stroke, epilepsy, and depression.
Approach:
- The review analyzes active constituents like bacosides and their metabolites.
- Mechanisms of action involve modulation of neurotransmission, neurogenesis, plasticity, and cellular pathways.
- Discussion includes clinical trials, safety, formulations, and combinations.
Key Points:
- BM's therapeutic effects are attributed to compounds such as bacoside A and B.
- Mechanisms include influencing neurotransmission, neurogenesis, oxidative stress, and inflammation.
- Emerging formulation technologies and clinical trial strategies are discussed.
Conclusions:
- Bacopa monnieri demonstrates broad therapeutic potential for various brain disorders.
- Improved brain delivery and well-designed clinical trials are crucial for its translation.
- Further research is needed to optimize its use in neurological conditions.
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