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Potential Therapeutic Application of Local Anesthetics in Cancer Treatment

Zhaosheng Jin1, William Zhang1, Hengrui Liu1

  • 1Department of Anesthesiology, Stony Brook University Health Science Center, Stony Brook, NY 11794, USA.

Recent Patents on Anti-Cancer Drug Discovery
|January 19, 2022
PubMed

Insights

Local anesthetics, known sodium channel blockers, show direct effects on cancer cells in vitro. This review explores their potential role in cancer treatment, examining both direct and indirect impacts.

Area of Science:

  • Oncology
  • Anesthesiology
  • Pharmacology

Background:

  • Local anesthetics (LAs) are voltage-gated sodium channel blockers used for anesthesia and analgesia.
  • In vitro studies indicate LAs directly affect cancer cell proliferation, apoptosis, migration, invasion, and chemosensitivity.
  • In vivo evidence on LAs' effects on cancer cell lines is limited.

Purpose of the Study:

  • To review the direct and indirect effects of local anesthetics on cancer cells.
  • To discuss current evidence regarding the use of local anesthetics in cancer treatment.

Main Methods:

  • Literature review of in vitro and in vivo studies.
  • Analysis of clinical evidence on local and regional anesthesia in cancer care.

Main Results:

  • Local anesthetics demonstrate direct anti-cancer effects in laboratory settings.
  • Regional anesthesia may reduce postoperative pain and opioid use in cancer patients.
  • Perioperative stress response might be mitigated by regional anesthesia.

Conclusions:

  • Local anesthetics exhibit multifaceted effects on cancer cells.
  • Clinical application of LAs in cancer therapy is an emerging area requiring further investigation.
Keywords:
Cancerimmunomodulationion channelslocal anestheticsopioidspainstress response

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