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Endogenous opioids and post-ictal increase in seizure threshold in Mongolian gerbils
1Laboratory of Pharmacology and Toxicology, School of Veterinary Medicine, Free University of Berlin, F.R.G.
Epilepsy Research
|March 1, 1987
Abstract:
In gerbils, the convulsive thresholds both for electroconvulsions and for pentetrazole-induced convulsions were increased when determined 15 min after a convulsion elicited by an air blast to the back of the animals. Contrary to a recently offered hypothesis, this sign of post-ictal depression could not be reversed by pretreatment with the morphine antagonists naloxone and naltrexone. This result speaks against a mediation of post-ictal depression by endogenous opioids.