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The Diagnostic Value of Presepsin in Acute Appendicitis and Reference Ranges for Healthy Children

Yilmaz Seçilmiş1, Pinar Sağiroğlu2, Ahmet Burak Doğan3

  • 1Department of Pediatrics, Division of Pediatric Emergency, Erciyes University, Faculty of Medicine, Kayseri 38039, Turkey.

Journal of Tropical Pediatrics
|January 19, 2022
PubMed

Insights

Presepsin is not a reliable diagnostic marker for pediatric appendicitis. This study found no significant difference in presepsin levels between children with appendicitis and healthy controls.

Area of Science:

  • Pediatric Emergency Medicine
  • Clinical Diagnostics
  • Inflammatory Markers

Background:

  • Appendicitis is a common surgical emergency in children.
  • Accurate and timely diagnosis is crucial to prevent complications.
  • Novel inflammatory markers are continuously being investigated for improved diagnostic accuracy.

Purpose of the Study:

  • To evaluate the diagnostic utility of presepsin as an inflammatory marker for pediatric appendicitis.
  • To establish a reference range for serum presepsin levels in healthy children.

Main Methods:

  • Prospective, single-center study in a pediatric emergency department.
  • Inclusion of children (0-18 years) with pathologically confirmed appendicitis and healthy volunteers.
  • Serum presepsin levels measured via ELISA, alongside other acute-phase reactants, appendicitis scores, and imaging.

Main Results:

  • No statistically significant difference in serum presepsin levels was observed between 94 pediatric appendicitis patients and 102 healthy controls (p=0.544).
  • Presepsin levels did not differ significantly between acute and perforated appendicitis groups (p=0.344).
  • The median reference range for presepsin in healthy children was determined as 0.9950 (0.7575-1.610) ng/mL.

Conclusions:

  • Serum presepsin is not a suitable diagnostic marker for acute appendicitis in children.
  • Contrary to some previous findings, presepsin levels were not elevated in pediatric appendicitis, a localized infection.
Abstract

Keywords:
paediatric appendicitispresepsinsCD14white blood cell

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