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Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

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Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
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IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
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[Drug-drug interactions with Mexidol in patients with ischemic stroke: Analysis of data from randomized clinical trials].

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[Multimodal antioxidant therapy in ischemic stroke: from MIR trial to bedside].

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Related Experiment Video

Updated: Oct 6, 2025

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
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[COVID-19 related stroke].

I A Shchukin1, M S Fidler1, I A Koltsov1

  • 1Pirogov Russian National Research Medical University, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|January 19, 2022
PubMed
Summary
This summary is machine-generated.

The COVID-19 pandemic increased stroke risk, including ischemic and hemorrhagic types. Antioxidant therapies may help manage these severe neurological complications.

Keywords:
ACE-2 receptorsCOVID-19cytokine stormischemic strokeoxidative storm mexidol

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiovascular Science

Background:

  • The COVID-19 pandemic significantly altered the incidence of acute cerebral circulatory disorders and mortality patterns.
  • SARS-CoV-2 infection is linked to an elevated risk of both ischemic and hemorrhagic stroke.

Purpose of the Study:

  • To elucidate the pathogenetic mechanisms linking COVID-19 to cerebral stroke.
  • To explore potential therapeutic interventions for stroke in COVID-19 patients.

Main Methods:

  • Analysis of key pathogenetic factors in COVID-19 associated stroke.
  • Review of systemic and cerebral ischemia mechanisms.
  • Evaluation of therapeutic limitations and potential antioxidant strategies.

Main Results:

  • COVID-19 stroke pathogenesis involves angiotensin 2 receptor dysfunction, endothelial damage, hypercoagulation, and oxidative stress.
  • Cerebral lesion severity in stroke patients with COVID-19 is associated with dual systemic and cerebral ischemia.
  • Current medical interventions for these complex conditions are limited.

Conclusions:

  • COVID-19 presents a complex challenge for managing cerebral circulatory disorders.
  • Antioxidant substances show potential as a therapeutic avenue for stroke patients with COVID-19.