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Simultaneous 3D Analysis of Cardiac Damage and Immune Response in Reperfused Acute Myocardial Infarction Using Light Sheet Fluorescence Microscopy
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Systemic immune-inflammation index predicts in-hospital and long-term outcomes in patients with ST-segment elevation

Lütfi Öcal1, Muhammed Keskin2, Sinan Cerşit1,3

  • 1Department of Cardiology, Health Sciences University, Kartal Koşuyolu Heart Training and Research Hospital.

Coronary Artery Disease
|January 19, 2022
PubMed

Insights

The systemic immune-inflammation index (SII) effectively predicts outcomes in ST-segment elevation myocardial infarction (STEMI) patients after primary percutaneous coronary intervention (pPCI). Higher SII levels correlate with increased risks of mortality and adverse events.

Area of Science:

  • Cardiology
  • Inflammation Research
  • Biomarker Discovery

Background:

  • ST-segment elevation myocardial infarction (STEMI) is a critical cardiovascular emergency.
  • Predictive biomarkers are crucial for managing STEMI patients undergoing primary percutaneous coronary intervention (pPCI).
  • The systemic immune-inflammation index (SII) is a novel biomarker derived from neutrophil, platelet, and lymphocyte counts.

Purpose of the Study:

  • To evaluate the predictive value of the systemic immune-inflammation index (SII) in patients with STEMI.
  • To assess the association between SII levels and in-hospital and long-term outcomes following pPCI.
  • To compare the predictive performance of SII against traditional risk factors.

Main Methods:

  • A cohort of 1660 STEMI patients undergoing pPCI was analyzed.
  • Patients were stratified into four groups (Q1-Q4) based on SII levels.
  • In-hospital and 3-year outcomes, including mortality and major adverse cardiac events, were compared across SII groups.

Main Results:

  • Higher SII groups (Q3 and Q4) showed significantly increased frequencies of in-hospital complications and mortality.
  • Logistic and Cox regression models identified high SII as an independent risk factor for mortality and cardiogenic shock.
  • Receiver operating characteristic analysis indicated an optimal SII cutoff of 1781 for predicting in-hospital mortality.

Conclusions:

  • The systemic immune-inflammation index (SII) is a valuable predictor of both in-hospital and long-term outcomes in STEMI patients post-pPCI.
  • SII demonstrates superior predictive capability compared to traditional risk factors for adverse events.
  • The findings support the use of SII in risk stratification and management strategies for STEMI patients.
Abstract

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