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[Reduce the distance between knowledge and practice.]

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Ten years post-Alessandro Liberati, the Italian Cochrane Center reflects on healthcare shifts. Evidence-based medicine faces challenges from precision medicine and trial biases, yet educational initiatives persist.

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Area of Science:

  • Healthcare research and policy
  • Evidence-based medicine
  • Medical innovation

Background:

  • Reflections on changes in international and Italian healthcare ten years after Alessandro Liberati's passing.
  • Concerns regarding the evolving nature of the Cochrane network, perceived as increasingly marketing-oriented.
  • Challenges to evidence-based medicine (EBM) from precision medicine and biases in randomized controlled trials (RCTs).

Purpose of the Study:

  • To assess the evolution of healthcare systems and research practices.
  • To evaluate the impact of changing research paradigms on EBM.
  • To highlight ongoing efforts in promoting EBM in Italy.

Main Methods:

  • Qualitative analysis of changes in healthcare and research networks.
  • Discussion of the influence of precision medicine on EBM.
  • Review of methodological quality versus theoretical value in research.

Main Results:

  • A perceived loss of cohesion within the Cochrane network.
  • Increased emphasis on methodological quality in research over theoretical study value.
  • The persistence of bias within randomized controlled trials.
  • Continued commitment to disseminating EBM through educational projects in Italy.

Conclusions:

  • While EBM faces challenges, its promotion among Italian professionals remains a priority.
  • Educational initiatives are crucial for navigating innovation and its limitations in medicine.
  • The shift towards methodological rigor is a significant trend in contemporary research.