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Updated: Jul 29, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
In vitro release behaviour of theophylline from PIB-induced ethylcellulose microcapsules interpreted by simple
1Department of Medical Research, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Abstract:
Theophylline microcapsules were prepared by phase separation using polyisobutylene as a coacervation-inducing agent. The release rate was dependent on the molecular weight of the polyisobutylene used. A simple mathematical function has been used for the quantitative description of the release process of the drug from PIB-induced microcapsules. It was found that 1/y = A(1/x) + B is the best for interpreting the release process of microcapsules, since the values of the constants A and B are proportional to the amount of the drug released.
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