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Reporting bias in clinical trials: Progress toward transparency and next steps
Mayookha Mitra-Majumdar1, Aaron S Kesselheim1
1Program On Regulation, Therapeutics, And Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Plos Medicine
|January 19, 2022
Summary
This review examines efforts to reduce reporting bias in clinical trials over 20 years. Strategies have evolved to improve the transparency and reliability of trial data.
Area of Science:
- Clinical trial methodology
- Medical research integrity
- Publication bias
Background:
- Reporting bias in clinical trials remains a significant challenge.
- Incomplete or selective reporting of trial outcomes can distort evidence.
Purpose of the Study:
- To review advancements in combating reporting bias in clinical trials.
- To assess the impact of interventions over the past two decades.
Main Methods:
- Literature review of policies and initiatives.
- Analysis of trends in clinical trial reporting.
Main Results:
- Increased awareness and regulatory efforts to address bias.
- Development of tools and guidelines to promote comprehensive reporting.
Conclusions:
- Progress has been made, but vigilance is still required.
- Continued efforts are necessary to ensure unbiased reporting in medical research.
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