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Updated: Oct 6, 2025

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
Substantial heterogeneity found in reporting mortality in Cochrane systematic reviews and Core Outcome Sets in COMET
Eve Tomlinson1, Jordi Pardo Pardo2, Susanna Dodd3
1Cochrane Gynaecological, Neuro-oncology and Orphan Cancers Group, Royal United Hospitals NHS Foundation Trust, Bath, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK..
Objective:
To explore mortality outcome usage in Cochrane systematic reviews and Core Outcome Sets for research.
Study Design And Setting:
Cochrane PICO searches identified Cochrane reviews (published January 2015-March 2021) including mortality outcomes. These outcomes were categorized according to terminology used: all-cause mortality, cause-specific mortality, infant mortality, maternal mortality, survival. Mortality outcomes in Core Outcome Sets (published until 2019 on the Core Outcome Measures in Effectiveness Trials (COMET) database) were also extracted and categorized.
Results:
In total, 2454 mortality outcomes were reported in 49% (1978/3999) of Cochrane reviews published January 2015-March 2021: all-cause (37%), infant (23%), maternal (11%), survival (10%), cause-specific (9%). Due to reviews not specifying mortality outcome type or including studies reporting no data, 11% (273/2208) remained uncategorized. Infant mortality and maternal mortality were frequently used together in reviews reporting two mortality outcomes. In total, 226 mortality outcomes were reported in 37% (165/449) of Core Outcome Sets: all-cause (48%), survival (27%), cause-specific (12%), infant (9%), maternal (4%). Mortality measurement timing varied.
Conclusion:
Mortality outcome usage varies in Cochrane reviews and Core Outcome Sets. This is problematic for evidence-based decision-making. Greater standardization is necessary for effective utilization of health research.
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