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Parkinsonism induced by high-dose cytosine arabinoside
F A Luque1, J B Selhorst, P Petruska
1Department of Neurology, Saint Louis University School of Medicine, Missouri 63110.
Abstract:
We report a severe parkinsonian condition following high dose, parenteral cytosine arabinoside (Cytosar) that persisted for 8 weeks. The drug was used in a patient with acute myelogenous leukemia that was refractory to all other treatment. The syndrome was partially responsive to antiparkinsonian drugs and fortunately remitted completely within 12 weeks.